Neha Saxena began her acting career with a leading role in Kannada movie Q. She won acclaim for her performance in Tulu cinema, Rickshaw Driver. She went on to win multiple awards including the Karnataka state award. Her Mollywood debut was Kasaba with Malayalam Super Star Mammootty. Neha’s portrayal of a sex worker, Susan, who helps the police officer, Mammootty, to save the others in her brothel, in Kasaba won her praise.